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. 2022 Jun 24;24(2):280. doi: 10.3892/ol.2022.13400

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Copyright: © Luo et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 6. — PVT1 regulates colon cancer cell 5-FU resistance via the miR-486-5p/CDK4 axis. (A) CCK-8 assay was used to detect the effects of the PVT1/miR-486-5p/CDK4 regulatory axis on the proliferation of HCT116-5FU-resistant cells. (B and C) A clone formation assay was used to assess the effects of the PVT1/miR-486-5p/CDK4 regulatory axis on clone formation by HCT116-5FU drug-resistant cells. (D) Flow cytometry was used to detect the effect of the PVT1/miR-486-5p/CDK4 regulatory axis on the cell cycle progression of HCT116-5FU drug-resistant cells. *P<0.05. PVT1, plasmacytoma variant translocation 1; 5-FU, 5-fluorouracil.