Table 4. Yields of Constituents Not in the FDA List of HPHCs that Are Higher in IQOS Aerosol than in 3R4F Smoke under the HCI Regimena.
| St. Helen et al.26 | Bentley et al.52 | ||
|---|---|---|---|
| constituents detected | amount per THS 2.2 heatstick | amount per THS 2.2 heatstick | range of values obtained per 3R4F cigarette26,52 |
| acids | |||
| benzoic acid, 2,5-dihydroxy-methyl (μg) | 4.55 (209)b | 2.18 | |
| 3-methylvaleric acid (μg) | 5.1 (140)b | 3.63 | |
| 3-methylpentanoic acid (μg) | 14.5 (113)b | 12.8 | |
| carbonyls | |||
| ethyl linoleate (μg) | 0.135 (1688)b | 0.008 | |
| ethyl linolenate (μg) | 0.614 (401)b | 0.153 | |
| 2-furancarboxaldehyde,5-methyl (μg) | 11.1 (378)b | 2.94 | |
| ethyl dodecanoate (ethyl laurate) (μg) | 0.023 | not detected | |
| hexadecanoic acid, ethyl ester (μg) | 0.491 (6138)b | 6.43 (6430)b | 0.008–0.1 |
| phenylacetaldehyde (μg) | 1.41 (267)b | 0.529 | |
| stearate, ethyl (μg) | 0.074 (2467)b | 0.003 | |
| glycols | |||
| propylene glycol (μg) | 175 (738)b | 643 (717)b | 23.7–89.6 |
| hydrocarbons | |||
| heptacosane (μg) | 10.2 (121)b | 8.41 | |
| benzene, 1,2,3,4-tetramethyl-4-(1-methylethenyl) (μg) | 0.006 (120)b | 0.005 | |
| butylated hydroxytoluene (μg) | 0.132 (1886)b | 0.007 | |
| eicosane, 2-methyl (μg) | 0.05 (357)b | 0.014 | |
| heneicosane, 2-methyl (μg) | 0.063 (300)b | 0.021 | |
| nitrogen compounds | |||
| 2-formyl-1-methylpyrrole (μg) | 0.128 (200)b | 0.064 | |
| 4(H)-pyridine, N-acetyl (μg) | 0.296 (264)b | 0.112 | |
| isoquinoline, 3-methyl (μg) | 6.29 (126)b | 4.99 | |
| maltoxazine (μg) | 0.077 (203)b | 0.038 | |
| pyridoxin (μg) | 0.699 (133)b | 0.526 | |
| other constituents | |||
| 1,2-propanediol, 3-chloro (μg) | 9.94 (168)b | 5.93 | |
| 1H-indene, 2,3-dihydro-1,1,5,6-tetramethyl (μg) | 0.026 (186)b | 0.014 | |
| 3-chloro-1,2-propanediol (μg) | 16.1 (196)b | 8.21 | |
| cis-sesquisabinene hydrate (μg) | 0.061 | not detected | |
| ergosterol (μg) | 3.18 (201)b | 1.58 | |
| labdane-8,15-diol, (13S) (μg) | 0.143 (953)b | 0.015 | |
| lanost-8-en-3-ol, 24-methylene-, (3beta) (μg) | 6.3 (391)b | 1.61 | |
| α-cembratriene-diol (μg) | 8.49 (2160)b | 0.393 | |
| p-menthan-3-ol (μg) | 0.786 (244)b | 0.322 | |
| other oxygenated compounds | |||
| furfural (μg) | 31.1 (120)b | 47.4 (124)b | 25.9–38.3 |
| trans-4-hydroxymethyl-2-methyl-1,3-dioxolane (μg) | 2.09 (4750)b | 0.044 | |
| 1-acetyloxy-2-propanone (μg) | 12.2 (132)b | 9.23 | |
| 2-monoacetin (μg) | 46.8 (156)b | 30 | |
| 1,2,3-propanetriol, diacetate (diacetin) (μg) | 1.23 (323)b | 0.381 | |
| 1,4-dioxane, 2-ethyl-5-methyl (μg) | 0.055 (13750)b | 0.0004 | |
| 12,14-labdadiene-7,8-diol, (8a,12E) (μg) | 1.43 (2234)b | 0.064 | |
| 1-hydroxy-2-butanone (μg) | 0.947 (204)b | 0.465 | |
| 1-hydroxy-2-propanone(1,2-propenediol) (μg) | 162 (167)b | 1135 (226)b | 96.8–502 |
| 2 (5H)-furanone (μg) | 5.32 (267)b | 1.99 | |
| 2H-pyran-2-one, tetrahydro-5-hydroxy (μg) | 8.16 (196)b | 4.13 | |
| 2,3-dihydro-5-hydroxy-6-methyl-4H-pyran-4-one (μg) | 0.231 (171)b | 0.135 | |
| 2-cyclopentene-1,4-dione (μg) | 3.8 (497)b | 8.4 (418)b | 0.764–2.01 |
| 2,4-dimethylcyclopent-4-ene-1,3-dione (μg) | 0.333 (173)b | 0.193 | |
| 2(5H)-furanone (μg) | 5.45 (256)b | 2.13 | |
| 2-furanmethanol (μg) | 39.2 (560)b | 37.5 (396)b | 7–9.47 |
| 2-furanmethanol, 5-methyl (μg) | 0.123 (424)b | 0.029 | |
| 2H-pyran-2-one, tetrahydro-5-hydroxy (μg) | 4.45 (143)b | 3.11 | |
| 2-methylcyclobutane-1,3-dione (μg) | 2.78 (392)b | 0.71 | |
| 2-propanone, 1-(acetyloxy) (μg) | 16.9 (211)b | 8.01 | |
| 3 (2H)-furanone, dihydro-2-methyl (μg) | 0.326 (274)b | 0.119 | |
| 5-methylfurfural (μg) | 0.995 (157)b | 14.2 (270)b | 0.632–5.25 |
| anhydro linalool oxide (μg) | 0.457 (157)b | 0.291 | |
| benzenemethanol, 4-hydroxy (μg) | 0.011 | not detected | |
| butyrolactone (μg) | 4.08 (560)b | 4.8 (444)b | 0.728–1.08 |
| cyclohexane, 1,2-dioxo (μg) | 0.083 (180)b | 0.046 | |
| cyclohexane-1,2-dione, 3-methyl (μg) | 0.101 (138)b | 0.073 | |
| ethyl 2,4-dioxohexanoate (μg) | 6.73 (189)b | 3.57 | |
| isolinderanolide (μg) | 4.99 (270)b | 1.85 | |
| methyl furoate (μg) | 0.147 (507)b | 0.029 | |
| pyranone (μg) | 6.54 (129)b | 51.4 (116)b | 5.07–44.5 |
| pyranone (μg) | 9.26 (159)b | 5.84 | |
a
The results compare the yields from an IQOS stick with the reference 3R4F cigarette, however, on an equivalent tobacco basis, the IQOS yields should be multiplied by at least 3.2. HCI, Health Canada Intense smoking regimen.
b
Compound in IQOS aerosol as a percentage of amount in 3R4F reference cigarette smoke.