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. 2022 Jul 6;10(7):e004616. doi: 10.1136/jitc-2022-004616

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See https://creativecommons.org/licenses/by/4.0/.

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SCD1-related free fatty acids and ratio are potential biomarkers to predict PD-1 antibody responses and prognosis. (A) Pretreatment serum levels of palmitic and palmitoleic acid and ratio of palmitoleic/palmitic acid from NSCLC patients who subsequently did (Responder, n=6) or did not (Non-responder, n=18) respond to anti-PD-1 antibody treatment. (B, C) Kaplan–Meier analyses of NSCLC patients before anti-PD-1 antibody treatment. Kaplan–Meier curve of high (n=12) and low (n=12) palmitic acid, palmitoleic acid and palmitoleic/palmitic acid ratio in the serum of PFS patients (B) (HR 0.34, 95% CI 0.13 to 0.85; HR 0.32, 95% CI 0.13 to 0.77; HR 0.35, 95% CI 0.14 to 0.87, respectively) or OS patients (C) (HR 0.34, 95% CI 0.12 to 0.94; HR 0.25, 95% CI 0.09 to 0.69; HR 0.25, 95% CI 0.09 to 0.71, respectively). The threshold between high and low was median (palmitic acid; 1.33, palmitoleic acid; 0.10, palmitoleic/palmitic acid ratio; 0.10).