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Potential clinical interest of imaging biomarkers for radiotherapy-immunotherapy combinations. Lesion-level analyses may help to identify potential immune-refractory lesions (high-risk lesions) needing focal destruction with ablative SBRT (high dose RT) or immunogenic lesions for which low dose RT may improve systemic response. Patient-level analyses allow overall response prediction. RT, radiotherapy; SBRT, stereotactic body radiation therapy.
