Table 2:
Primary Cause of Death by Conditioning Intensity
| Primary cause of death | Conditioning intensity | |||
|---|---|---|---|---|
| MAC N (%) | RIC N (%) | Unknown N (%) | Total N (%) | |
| Total number of deaths | 151 | 81 | 3 | 235 |
| Treatment related | 58 (38.4) | 17 (20.9) | 1 (33.3) | 68 (32.3) |
| Acute GVHD | 7 (4.6) | 1 (1.2) | 0 (0.0) | 8 (3.4) |
| Chronic GVHD | 8 (5.3) | 4 (4.9) | 0 (0.0) | 12 (5.1) |
| Graft rejection or failure | 6 (4.0) | 0 (0.0) | 0 (0.0) | 6 (2.6) |
| Infection* | 11 (7.3) | 5 (6.2) | 0 (0.0) | 16 (6.8) |
| Organ failure (not due to GVHD or infection) | 20 (13.3) | 6 (7.4) | 0 (0.0) | 26 (11.1) |
| Pulmonary complications | 6 (4.0) | 1 (1.2) | 1 (33.3) | 8 (3.4) |
| Malignancy# | 3 (2.0) | 7 (8.6) | 0 (0.0) | 10 (4.3) |
| Relapse / persistence / progression of disease | 70 (46.4) | 37 (45.7) | 1 (33.3) | 108 (46.0) |
| Other | 2 (1.3) | 1 (1.2) | 0 (0.0) | 3 (1.3) |
| Unknown | 18 (11.9) | 19 (23.5) | 1 (33.3) | 38 (16.2) |
*
Infection (isolation of an organism leading to sepsis/organ failure with no other ascertainable cause of death in the previous 7 days)
#
Malignancy refers to a malignancy unrelated to the therapy-related myeloid neoplasm diagnosis.
Abbreviations: GVHD: graft-versus-host disease; MAC: myeloablative conditioning; RIC: reduced-intensity conditioning.