Table 2.

Novel potential molecular targets identified using intestinal organoids

Potential molecular targets	Effect	Species	Ref.
LRH-1	Improved resistance to pro-inflammatory mediators and induced mucosal healing	Humanized mouse (Lrh-1-/- LRH-1+/+) and Human	[94]
PXR	Reduced NF-kB activity	Human (IBD patients)	[97]
IL-22-pSTAT3 SP	Restored tissue damage and intestinal homeostasis	Mouse (ATF3-/-)	[98]
TGF-β SP	Arrested inflammatory signals	Mouse	[104]
SIRT2	Regulated Wnt/β-catenin SP	Mouse (Sirt2–/–)	[105]

ATF3: Activating transcription factor 3; IBD: Inflammatory bowel disease; IL: Interleukin; LRH-1: Liver receptor homolog 1; NF-kB: Nuclear factor-kappa B; PXR: Pregnane X receptor; SIRT2: Human sirtuin protein 2; SP: Signaling pathway; STAT: Signal transducer and activator of transcription; TGF-β: Transforming growth factor Β.