Table 3.

Potential therapeutic approaches for inflammatory bowel disease treatment identified using intestinal organoids

Potential therapeutic approaches	Effect	Species	Ref.
Sex hormones	Decreased expression of ER stress markers	Human (UC female patients)	[100]
Naltrexone	Reduced ER stress levels, increased the expression of endogenous encephalins and endorphins	Human (IBD patients)	[101]
Bacillus subtilis (RZ001)	Promoted intestinal mucosa repair	Mouse	[102]
Bacterial indoleacrylic acid	Promoted anti-inflammatory cytokines secretion while inducing goblet cells differentiation	Mouse	[103]
Hyaluronan 35 kDa	Promoted epithelial wound healing	Mouse	[106]

ER: Endoplasmic reticulum; IBD: Inflammatory bowel disease; UC: Ulcerative colitis.