Table 6.
Summary of the predictive performance of the studied plasma biomarkers
|
|
AUROC
|
Cut-off value
|
SS
|
SP
|
NPV
|
PPV
|
PLR
|
NLR
|
| WBC in g/L | ||||||||
| POD3 | 0.57 | 9.75 | 0.46 | 0.75 | 0.95 | 0.11 | 1.84 | 0.72 |
| POD4 | 0.60 | 8.25 | 0.52 | 0.68 | 0.96 | 0.10 | 1.64 | 0.70 |
| POD5 | 0.62 | 7.55 | 0.56 | 0.62 | 0.95 | 0.09 | 1.48 | 0.71 |
| ECC in cells/μL | ||||||||
| POD3 | 0.59 | 150 | 0.50 | 0.59 | 0.95 | 0.08 | 1.23 | 0.84 |
| POD4 | 0.54 | 150 | 0.33 | 0.71 | 0.94 | 0.07 | 1.14 | 0.94 |
| POD5 | 0.70 | 250 | 0.89 | 0.43 | 0.98 | 0.10 | 1.55 | 0.26 |
| CRP in mg/L | ||||||||
| POD3 | 0.76 | 175.90 | 0.64 | 0.83 | 0.97 | 0.20 | 3.77 | 0.44 |
| POD4 | 0.76 | 152.40 | 0.62 | 0.89 | 0.97 | 0.27 | 5.40 | 0.43 |
| POD5 | 0.81 | 96.80 | 0.78 | 0.78 | 0.98 | 0.19 | 3.48 | 0.29 |
| PCT in ng/mL | ||||||||
| POD3 | 0.57 | 0.19 | 0.68 | 0.47 | 0.96 | 0.08 | 1.28 | 0.68 |
| POD4 | 0.50 | 0.31 | 0.38 | 0.76 | 0.95 | 0.10 | 1.56 | 0.82 |
| POD5 | 0.61 | 0.39 | 0.44 | 0.79 | 0.96 | 0.12 | 2.10 | 0.71 |
| CLP in μg/mL | ||||||||
| POD3 | 0.78 | 6.57 | 0.71 | 0.72 | 0.97 | 0.15 | 2.55 | 0.40 |
| POD4 | 0.67 | 8.34 | 0.56 | 0.86 | 0.97 | 0.21 | 3.89 | 0.51 |
| POD5 | 0.65 | 6.98 | 0.58 | 0.80 | 0.97 | 0.16 | 2.84 | 0.52 |
AUROC: Area under the receiver operating characteristic curve; SS: Sensitivity; SP: Specificity; NPV: Negative predictive value; PPV: Positive predictive value; PLR: Positive likelihood ratio; NLR: Negative likelihood ratio; WBC: White blood cell count; POD: Postoperative day; ECC: Eosinophil cell count; CRP: C-reactive protein; PCT: Procalcitonin; CLP: Calprotectin.