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. 2022 Jun 22;7(26):22531–22550. doi: 10.1021/acsomega.2c01820

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© 2022 The Authors. Published by American Chemical Society

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Visual representation of the protein–protein interaction (PPI) network of overlapped DEGs and the hub genes. (a) PPI network constructed by overlapping genes. The thickness of the connection line indicates the level of betweenness within proteins. Color gradients from cyan to pink of nodes represent the change of log FC. Green color denotes the coexpression nodes added by the STRING database. (b) Top 15 hub genes screened by cytoHubba plugin of Cytoscape based on the MNC score where a higher score is represented in red color and a lower score in yellow color, (c) Venn diagram representing the overlapping hub genes within these four methods, and (d) GO and KEGG enrichment analyses of 12 hub genes.