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. 2022 Jun 22;7(26):22531–22550. doi: 10.1021/acsomega.2c01820

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© 2022 The Authors. Published by American Chemical Society

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Representative box plots for the validated result of six overlapping hub gene expression levels in GBM and LGG in comparison with N. (a) Validation result of gene expression levels through the GEPIA2 server. TCGA_GBM tissues (n = 163) and TCGA_LGG tissues (n = 518) marked in red color and noncancerous tissues marked in gray (n = 207); a red asterisk indicates a p-value <0.01. (b) Cross-validation of hub gene expression levels in glioma and normal samples based on GSE4290. Two-tailed Student t-tests were used to assess the statistical significance of differences. These results indicate that our findings are reliable with P < .05. GBM: glioblastoma, LGG: low-grade glioma, and N: normal.