| Upregulated Genes |
| BP:GO:0009952∼anterior/posterior
pattern specification |
5 |
1.00 × 10–5
|
HEY1, HOXA6, HOXD9, HOXC8, HOXA11 |
| MF:GO:1990837∼sequence-specific
double-stranded DNA binding |
7 |
2.10 × 10–4
|
HEY1, GSC, SHOX2, HOXA6, HOXD9, HOXC8, HOXA11 |
| BP:GO:0035115∼embryonic
forelimb morphogenesis |
3 |
9.70 × 10–4
|
SHOX2, HOXD9, HOXA11 |
| BP:GO:0048704∼embryonic
skeletal system morphogenesis |
3 |
0.0016 |
GSC, HOXA6, HOXD9 |
| BP:GO:0000122∼negative
regulation of transcription from the RNA polymerase II promoter |
7 |
0.0021 |
SOX2, HEY1, GSC, SHOX2,
ARID5A, HOXD9, HOXC8 |
| BP:GO:0006357∼regulation
of transcription from the RNA polymerase II promoter |
9 |
0.0023 |
HEY1, GSC, SHOX2, ARID5A, ZNF107,
HOXA6, HOXD9, HOXC8, HOXA11 |
| MF:GO:0000981∼RNA polymerase
II transcription factor activity, sequence-specific DNA binding |
8 |
0.0034 |
SOX2, HEY1, GSC, SHOX2,
HOXA6, HOXD9, HOXC8, HOXA11 |
| CC:GO:0000785∼chromatin |
7 |
0.0035 |
SOX2, HEY1, GSC, SHOX2, HOXA6, HOXD9,
HOXC8 |
| CC:GO:0005667∼transcription
factor complex |
4 |
0.0046 |
SOX2, GSC, ARID5A, HOXA11 |
| BP:GO:0007155∼cell adhesion |
5 |
0.0077 |
TNC, ITGB8, PCDH12, PCDHB9,
FREM2 |
| BP:GO:0060351∼cartilage
development involved in endochondral bone morphogenesis |
2 |
0.01 |
SHOX2, HOXA11 |
| MF:GO:0000978∼RNA polymerase
II core promoter proximal region sequence-specific DNA binding |
7 |
0.01 |
SOX2, HEY1, GSC, ZNF107,
HOXA6, HOXD9, HOXA11 |
| BP:GO:0001649∼osteoblast
differentiation |
3 |
0.012 |
SOX2, SHOX2, TNC |
| BP:GO:0060272∼embryonic
skeletal joint morphogenesis |
2 |
0.014 |
SHOX2, HOXA11 |
| BP:GO:0009954∼proximal/distal
pattern formation |
2 |
0.036 |
HOXD9, HOXA11 |
| BP:GO:0045087∼innate
immune response |
4 |
0.055 |
HERC5, OAS3, ARID5A, TRIM14 |
| Downregulated Genes |
| MF:GO:0005200∼structural
constituent of the cytoskeleton |
3 |
0.0016 |
NEFM, SORBS2, INA |
| BP:GO:0071504∼cellular
response to heparin |
2 |
0.0025 |
SFRP1, SLIT2 |
| MF:GO:0043237∼laminin-1
binding |
2 |
0.0035 |
NTN4, SLIT2 |
| CC:GO:0005883∼neurofilament |
2 |
0.0054 |
NEFM, INA |
| BP:GO:0007411∼axon guidance |
3 |
0.0061 |
NTN4, SLIT2, L1CAM |
| BP:GO:0001657∼ureteric
bud development |
2 |
0.018 |
SFRP1, SLIT2 |
| CC:GO:0005886∼plasma
membrane |
7 |
0.031 |
MAGI1,
RAB3B, SFRP1, NTN4, SORBS2, L1CAM, PTPN3 |
| CC:GO:0009986∼cell surface |
3 |
0.043 |
SFRP1, SLIT2, L1CAM |
| BP:GO:0030154∼cell
differentiation |
3 |
0.044 |
SFRP1, SLIT2, INA |
| KEGG Pathway |
| UP_hsa04512:ECM–receptor
interaction |
3 |
0.007 |
TNC,
ITGB8, FREM2 |
| DOWN_hsa04360:axon guidance |
3 |
0.0048 |
NTN4,
SLIT2, L1CAM |
