Table 1. Reaction Condition Optimization of the Deacetylation of Compound 11^a.

entry	reagents	solvent	T (°C)	12 (% yield)b (%)	12a (% yield)b (%)
1	K2CO3c	MeOH/DCM	r.t. to 40 °Cd	0	0
2	10% LiOH	MeOH/DCM	r.t. to 40 °Cd	30	25
3	10% NaOH	MeOH/DCM	r.t. to 40 °Cd	51	19
4	10% KOH	MeOH/DCM	r.t. to 40 °Cd	47	23
5	LiAlH4	THF	0 °C to r.t.	81	0

^aReaction conditions: 11 (0.1 mmol), reagents (1.0 mmol, 10.0 equiv), solvent (3.0 mL, MeOH/DCM, v/v = 2:1), 16 h.

^bIsolate yield.

^cSaturated aqueous.

^dStirred at room temperature for 10 h (no reaction), then rise to 40 °C and stirred for another 6 h.