Table 8. Toxicity Prediction of All the Synthesized Compounds 4(a-o).
| compounds | rat male NTPa prediction | mouse male NTPa prediction | Ames mutagenicity prediction | skin irritation | aerobic biodegradability prediction |
|---|---|---|---|---|---|
| 4a | non-carcinogen (0.000) | non-carcinogen (0.000) | non-mutagen (0.000) | non-irritant (0.000) | non-biodegradable (0.000) |
| 4b | non-carcinogen (0.000) | non-carcinogen (0.000) | non-mutagen (0.000) | non-irritant (0.000) | non-biodegradable (0.000) |
| 4c | non-carcinogen (0.010) | non-carcinogen (0.000) | non-mutagen (0.000) | non-irritant (0.000) | non-biodegradable (0.000) |
| 4d | non-carcinogen (0.000) | non-carcinogen (0.000) | non-mutagen (0.000) | non-irritant (0.000) | non-biodegradable (0.000) |
| 4e | non-carcinogen (0.001) | non-carcinogen (0.000) | non-mutagen (0.094) | non-irritant (0.000) | non-biodegradable (0.000) |
| 4f | non-carcinogen (0.001) | non-carcinogen (0.000) | non-mutagen (0.022) | non-irritant (0.000) | non-biodegradable (0.000) |
| 4g | non-carcinogen (0.000) | non-carcinogen (0.000) | non-mutagen (0.000) | non-irritant (0.003) | non-biodegradable (0.131) |
| 4h | non-carcinogen (0.000) | non-carcinogen (0.000) | non-mutagen (0.000) | non-irritant (0.000) | biodegradable (1.000) |
| 4i | non-carcinogen (0.000) | non-carcinogen (0.000) | non-mutagen (0.000) | non-irritant (0.002) | non-biodegradable (0.000) |
| 4j | non-carcinogen (0.001) | non-carcinogen (0.000) | non-mutagen (0.002) | non-irritant (0.000) | non-biodegradable (0.000) |
| 4k | non-carcinogen (0.000) | non-carcinogen (0.000) | non-mutagen (0.000) | non-irritant (0.030) | non-biodegradable (0.000) |
| 4l | non-carcinogen (0.000) | non-carcinogen (0.000) | non-mutagen (0.000) | non-irritant (0.000) | non-biodegradable (0.000) |
| 4m | non-carcinogen (0.009) | non-carcinogen (0.000) | non-mutagen (0.000) | irritant (0.992) | non-biodegradable (0.000) |
| 4n | non-carcinogen (0.001) | non-carcinogen (0.000) | non-mutagen (0.008) | non-irritant (0.000) | non-biodegradable (0.002) |
| 4o | non-carcinogen (0.000) | non-carcinogen (0.000) | non-mutagen (0.000) | non-irritant (0.000) | non-biodegradable (0.016) |
a
NTP: National Toxicology Program.