Table 9. Physicochemical Properties of All of the Synthesized Compounds 4(a-o) and Standard Drugs on the Basis of Lipinski’s Rule of Fivea.
| compounds | MW(g/mol) | nHBA | nHBD | TPSA (Å2) | Log Po/w | nLV |
|---|---|---|---|---|---|---|
| 4a | 332.40 | 3 | 1 | 54.60 | 3.56 | 0 |
| 4b | 366.84 | 3 | 1 | 54.60 | 4.12 | 0 |
| 4c | 348.40 | 4 | 2 | 74.83 | 3.18 | 0 |
| 4d | 362.42 | 4 | 1 | 63.83 | 3.59 | 0 |
| 4e | 411.29 | 3 | 1 | 54.60 | 4.19 | 0 |
| 4f | 377.39 | 5 | 1 | 100.42 | 2.85 | 0 |
| 4g | 377.39 | 5 | 1 | 100.42 | 2.84 | 0 |
| 4h | 346.42 | 3 | 1 | 54.60 | 3.89 | 0 |
| 4i | 425.32 | 3 | 1 | 54.60 | 4.54 | 0 |
| 4j | 362.42 | 4 | 2 | 74.83 | 3.49 | 0 |
| 4k | 391.42 | 5 | 1 | 100.42 | 3.20 | 0 |
| 4l | 362.42 | 4 | 2 | 74.83 | 3.45 | 0 |
| 4m | 380.87 | 3 | 1 | 54.60 | 4.45 | 0 |
| 4n | 376.45 | 4 | 1 | 63.83 | 3.91 | 0 |
| 4o | 391.42 | 5 | 1 | 100.42 | 3.21 | 0 |
| alpidem | 404.33 | 2 | 0 | 37.61 | 4.89 | 0 |
| ciprofloxacin | 331.34 | 5 | 2 | 74.57 | 1.10 | 0 |
| GSK812397 | 402.35 | 7 | 1 | 60.14 | 2.44 | 0 |
| minodronic acid | 680.79 | 8 | 5 | 172.21 | –1.74 | 0 |
| miroprofen | 266.29 | 3 | 1 | 54.60 | 2.64 | 0 |
| necopidem | 363.50 | 2 | 0 | 37.61 | 4.40 | 0 |
| olprinone | 250.26 | 3 | 1 | 73.95 | 1.67 | 0 |
| saripidem | 341.83 | 2 | 0 | 37.61 | 3.66 | 0 |
| zolimidine | 272.32 | 3 | 0 | 59.82 | 2.25 | 0 |
| zolpidem | 307.39 | 2 | 0 | 37.61 | 3.13 | 0 |
a
MW molecular weight, nHBD number of hydrogen-bond donor, nHBA number of hydrogen-bond acceptor, TPSA topological polar surface area, Log Po/w octanol/water partition coefficient, nLV number of Lipinski violation.