Skip to main content
. 2022 Jun 23;7(26):22839–22849. doi: 10.1021/acsomega.2c02449

Table 2. Effect of Solvents in Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones/thiones (4–9).

solvent time (min) yield (%)a
DCM 30 39
DMF 30 46
THF 30 52
CH3CN 30 57
CHCl3 30 52
MeOH 20 79
ACOH 20 76
EtOH 6 90
H2O 6 89
H2O/EtOH 3 98
a

Isolated yields based on 4, 1 (1 mmol), 2a (1.5 mmol), and 3a (1 mmol) in a mixture of water and ethanol (3:1 ratio) by microwave irradiation condition, 3 min.