Table 1. Median and Range of PCB Neurotoxic Equivalents for PCB Homologue Groups and Total PCBs in Postmortem Human Brain Samples, Calculated Based on NEFs for Multiple Mechanisms of Actiona.
| PCB homologue | age | gender | brain region | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| older donors (n = 33) | younger donors (n = 30) | male donors (n = 13) | female donors (n = 50) | amy (n = 6) | BA19 (n = 11) | CB (n = 13) | CTX (n = 6) | HC (n = 10) | PFC (n = 8) | SN (n = 9) | |
| mono | 25 (ND, 46) | 66 (ND, 91) | 69 (ND, 91) | 37 (ND, 66) | 46 (ND, 0) | 35 (ND, 66) | 66 (ND, 91) | ND | ND | ND | ND |
| di | 10 (ND, 25) | 8 (ND, 50) | 8 (ND, 10) | 13 (ND, 50) | ND | 9 (ND, 10) | 17 (ND, 50) | ND | 8 (ND, 8) | ND | ND |
| tri | 2 (ND, 13) | 1 (ND, 93) | 3 (ND, 13) | 2 (ND, 93) | 1 (ND, 27) | 2 (ND, 5) | 3 (ND, 93) | 1 (ND, 1) | 3 (ND, 7) | 6 (ND, 8) | 4 (ND, 10) |
| tetra | 7 (ND, 94) | 3 (ND, 252) | 39 (ND, 83) | 3 (ND, 252) | 83 (ND, 141) | 69 (ND, 70) | 3 (ND, 252) | 2 (ND, 49) | 35 (ND, 67) | ND | 1 (ND, 80) |
| penta | 4 (ND, 377) | 3 (ND, 24) | 21 (ND, 60) | 3 (ND, 377) | 7 (ND, 174) | 48 (ND, 94) | 1 (ND, 377) | 2 (ND, 8) | 3 (ND, 9) | 2 (ND, 3) | 3 (ND, 244) |
| hexa | 93 (ND, 189) | 0.2 (ND, 86) | 100 (ND, 141) | 37 (ND, 189) | 82 (ND, 157) | 7 (ND, 158) | 25 (ND, 189) | 81 (ND, 106) | 74 (ND, 169) | 37 (ND, 76) | 90 (ND, 153) |
| hepta | 90 (ND, 174) | 1 (ND, 74) | 92 (ND, 174) | 57 (ND, 137) | 58 (ND, 79) | 48 (ND, 122) | 55 (ND, 100) | 84 (ND, 106) | 68 (ND, 142) | 5 (ND, 74) | 85 (ND, 133) |
| octa | 89 (ND, 157) | 3 (ND, 87) | 93 (ND, 157) | 79 (ND, 146) | 104 (ND, 104) | 92 (ND, 146) | 73 (ND, 96) | 94 (ND, 102) | 93 (ND, 134) | 7 (ND, 83) | 78 (ND, 89) |
| ΣNEQ | 290 (5, 858) | 7 (ND, 732) | 325 (ND, 628) | 64 (ND, 858) | 83 (ND, 274) | 74 (ND, 561) | 182 (ND, 858) | 242 (ND, 340) | 214 (ND, 467) | 12 (ND, 237) | 295 (ND, 545) |
a
NEQ values for individual tissue extracts were calculated based on the NEFs established for the PCB homologue groups based on multiple mechanisms of action.55 Data represent the median of the NEQ values of each homologue group across samples and the ΣNEQ from each sample. For analogous data based on NEFs established for the PCB homologue groups based on a single mechanism of action or NEFs established based on the number of ortho-chlorine substituents and a single or multiple mechanisms of action, see Table S10.