Table 3.
The geometric mean ratios of primary pharmacokinetic parameters for lisinopril and amlodipine and their 90%CIs under fasting and fed conditions
| Geometric mean | T/R (%) | Intra-CV (%) | 90%CIs | ||
|---|---|---|---|---|---|
| T | R | ||||
| Lisinopril, fasting | |||||
| Cmax(ng/mL) | 50.71 | 51.12 | 99.19 | 24.3 | 90.54 ~ 108.67 |
| AUC0-t(h × ng/mL) | 890.83 | 898.61 | 99.05 | 19.3 | 92.10 ~ 106.52 |
| AUC0-∞(h × ng/mL) | 982.55 | 991.14 | 99.13 | 17.0 | 92.97 ~ 105.71 |
| Amlodipine, fasting | |||||
| Cmax(ng/mL) | 2.23 | 2.25 | 99.3 | 9.7 | 95.70 ~ 103.04 |
| AUC0-t (h × ng/mL) | 112.1 | 113.27 | 98.97 | 9.9 | 95.30 ~ 102.78 |
| AUC0-∞(h × ng/mL) | 120.52 | 121.66 | 99.07 | 10.5 | 95.19 ~ 103.04 |
| Lisinopril, fed | |||||
| Cmax(ng/mL) | 13.49 | 13.11 | 102.95 | 22.4 | 94.28 ~ 112.41 |
| AUC0-t(h × ng/mL) | 376.67 | 383.16 | 98.31 | 13.3 | 93.28 ~ 103.61 |
| AUC0-∞(h × ng/mL) | 483.99 | 484.98 | 99.79 | 12.9 | 94.83 ~ 105.02 |
| Amlodipine, fed | |||||
| Cmax(ng/mL) | 1.88 | 1.9 | 98.94 | 11.6 | 94.51 ~ 103.57 |
| AUC0-t (h × ng/mL) | 105.04 | 112.61 | 93.28 | 9.3 | 89.92 ~ 96.77 |
| AUC0-∞(h × ng/mL) | 114.06 | 122.33 | 93.24 | 9.8 | 89.67 ~ 96.65 |
Abbreviation: CI Confidence interval, Intra-CV Intra-subject coefficient of variation