Table 2.
Outcomes of BAMBI, BASCET and BATSCH trials
| Domain | Outcome measure | BAMBI | BASCET | BATSCH |
|---|---|---|---|---|
| Behavioral outcomes | ||||
| Social communication and interaction | SRS-2 (subscales social awareness, social cognition, social communication, social motivation) | Xa | X | X |
| Restricted, repetitive patterns of behavior | SRS-2 (subscale mannerisms) | Xa | X | X |
| RBS-r | X | X | X | |
| Aberrant behavior | ABC | X | Xa | Xa |
| Sensitivity to sensory stimuli and Sensory stimulation tolerance | SP-NL | X | X | X |
| SP-SC | X | X | ||
| HSP | X | X | ||
| Quality of life and social improvement | ||||
| Quality of life | QoL | X | X | X |
| EQ-5D-5L | X | X | X | |
| EQ-5D-Y | X | X | X | |
| pedsQL | X | X | ||
| Executive functions | TRF | X | X | |
| BRIEF | X | X | ||
| Economic evaluation | iPCQ | X | X | |
| TIC-P | X | X | ||
| Disease specific outcomes | ||||
| TSC | TAND checklist | X | ||
| Epilepsy | Epilepsy variables | X | ||
| Cognitive measurements | ||||
| Working memory | Digit span of the WISC-III, spatial span of the Wechsler Nonverbal scale of ability | X | X | |
| Memory | Rey auditory verbal learning test, rey visual design learning test | X | X | |
| Semantic memory | Recalling sentences subtest of the clinical evaluation of language fundamentals | X | X | |
| Baseline response speed | ANT | X | X | |
| Prepotent response inhibition | Go-nogo task and condition two of the auditory and visual shifting set tasks of the ANT | X | X | |
| Attentional flexibility | Condition three of the auditory and visual shifting set tasks of the ANT | X | X | |
| Neurophysiological outcomes | ||||
| rsEEG | Alpha relative and absolute power, central frequency, detrended fluctuation analysis and excitation/inhibition ratio | X | X | |
| ERP | PPI paradigm, P50 paradigm, mismatch negativity paradigm, selective attention paradigm | X | X | |
Primary outcome measures are marked witha ABC Aberrant behavior scale, ANT Amsterdam neuropsychological task battery, BRIEF: behavior rating inventory of executive function, EQ-5D-5L 5-level EuroQoL 5-dimensional questionnaire, EQ-5D-Y 5-level EuroQoL 5-dimensional questionnaire, youth version, ERP: event-related potential, HSP highly sensitive child or parent scale, iPCQ productivity cost questionnaire, pedsQL pediatric quality of life inventory, QoL quality of life, RBS-r repetitive behavior scale revised, rsEEG resting state electro-encephalogram, SP-NL sensory profile, Dutch version, SP-SC sensory profile, school companion, SRS-2 social responsiveness scale, second edition, TAND tuberous sclerosis associated neuropsychiatric disorders, TiC-P Trimbos/iMTA questionnaire for Costs associated with Psychiatric Illness, TRF teacher report form, TSC tuberous sclerosis complex