Table 4.
Outcome measures
| Domain | Outcome measure |
|---|---|
| Primary outcome measures | |
| Behavioral domain | |
| Anxiety |
PROMIS Anxiety (v2.0) PROMIS Psychological stress experiences (v1.0) |
| Mood problems |
PROMIS Depressive symptoms (v2.0) PROMIS Life satisfaction (v1.0) |
| Sleep problems |
PROMIS Sleep-related impairment (v1.0) PROMIS Sleep disturbance (v1.0) |
| Fatigue | PROMIS Fatigue (v2.0) |
| Physical complaints | PROMIS Physical stress experiences (v1.0) |
| Daily functioning and participation | PROMIS Cognitive function (v.1.1), VABS |
| Problems in social interaction and communication | PROMIS Peer relationships (v2.0) |
| Secondary outcome measures | |
| Behavioral domain | |
| Social communication and interaction | SRS-2 (subscales social awareness, social cognition, social communication, social motivation) |
| Restricted, repetitive patterns of behavior |
SRS-2 (subscale mannerisms) RBS-r |
| Sensory stimulation tolerance | SP-NL |
| Sensitivity to sensory stimuli | SP-NL |
| Aberrant behavior | ABC |
| Functional domain | |
| Cognitive | Emma-toolbox |
| Neurophysiological | rsEEG |
| Translational domain | |
| Genetic | Whole exome sequencing |
| Cellular | Assays on iPSC-derived neuronal models |
ABC Aberrant behavior scale, PROMIS patient reported outcome measurement information system, RBS-r repetitive behavior scale revised, rsEEG resting state electro-encephalogram, SP-NL sensory profile, Dutch version, SRS-2 social responsiveness scale, second edition, VABS Vineland scale of adaptive behavior