Table 3.
Subgroup analyses of the relationship between ALP quintiles (Q1-Q5) and poor 3-month prognosis in AIS patients with preserved renal function
| Confounding factor category | ALP level quintiles(Q1-Q5) | P for trend | P for interaction | ||||
|---|---|---|---|---|---|---|---|
| Q1 | Q2 | Q3 | Q4 | Q5 | |||
| Age, years | 0.188 | ||||||
| < 65 | 2.28(0.69 ~ 7.52) | 3.39(1.03 ~ 11.1) | 5.33(1.76 ~ 16.16) | Reference | 4.78(1.59 ~ 14.33) | 0.434 | |
| ≥ 65 | 1.34(0.75 ~ 2.42) | 1.41(0.78 ~ 2.56) | 1.29(0.71 ~ 2.36) | Reference | 1.43(0.79 ~ 2.61) | 0.721 | |
| Sex | 0.243 | ||||||
| man | 1.83(0.89 ~ 3.76) | 2.39(1.17 ~ 4.87) | 2.83(1.39 ~ 5.77) | Reference | 2.24(1.07 ~ 4.67) | 0.620 | |
| women | 1.49(0.68 ~ 3.27) | 1.24(0.55 ~ 2.79) | 1.03(0.48 ~ 2.18) | Reference | 1.63(0.81 ~ 3.29) | 0.835 | |
| Drinking | 0.851 | ||||||
| yes | 1.55(0.88 ~ 2.71) | 1.8(1.02 ~ 3.18) | 1.76(1.01 ~ 3.07) | Reference | 1.97(1.15 ~ 3.38) | 0.979 | |
| no | 1.19(0.32 ~ 4.42) | 1.37(0.39 ~ 4.86) | 1.94(0.56 ~ 6.68) | Reference | 1.05(0.26 ~ 4.32) | 0.699 | |
| Hypertension | 0.647 | ||||||
| yes | 1.86(0.72 ~ 4.82) | 1.75(0.68 ~ 4.55) | 1.62(0.62 ~ 4.24) | Reference | 1.87(0.72 ~ 4.86) | 0.646 | |
| no | 1.29(0.69 ~ 2.4) | 1.55(0.83 ~ 2.89) | 1.82(1 ~ 3.29) | Reference | 1.78(0.99 ~ 3.22) | 0.696 | |
| Leukocyte count, × 109/L | 0.720 | ||||||
| < 10 | 1.71(0.98 ~ 2.99) | 1.9(1.08 ~ 3.35) | 1.94(1.12 ~ 3.37) | Reference | 1.99(1.14 ~ 3.45) | 0.683 | |
| ≥ 10 | 0.91(0.14 ~ 5.82) | 1.13(0.2 ~ 6.44) | 2.04(0.34 ~ 12.03) | Reference | 2.24(0.52 ~ 9.66) | 0.455 | |
Notes: adjusted for smoking, prior stroke, NIHSS score at admission, BMI, serum creatinine, eGFR; Pneumonia during hospitalization, atrial fibrillation, diabetes mellitus, ALT,
Abbreviations: ALP Alkaline phosphatase, eGFR estimated glomerular filtration rate, OR Odds ratios, CI Confidence interval, Q Quintiles
Q1: < 58.8 U/L, Q2: 58.8–69.5 U/L, Q3: 69.6–81.6 U/L, Q4: 81.7–97.5 U/L, Q5: ≥ 97.6 U/L