Table 2.
Demographic, clinical, and post-mortem characteristics for cortical frontal and temporal samples from the independent validation cohort
| FTD-GRN (N = 2) | FTD-MAPT (N = 3) | |||
|---|---|---|---|---|
| Demographics | ||||
| Female, n (%) | 2/2 (100.0) | 0/3 (0.0) | ||
| Age, median (range) | 63.5 (61–66) | 57.0 (55–65) | ||
| Clinical characteristics | ||||
| Genetic mutation (n) | S82fs (1) | A886G (1) | ||
| c.1179 + 104_1536delinsCTGA (1) | P301L (2) | |||
| Disease pathology (n) | ||||
| • Atypical Pick’s disease | – | 1 | ||
| • Tau | – | 2 | ||
| • TDP-type A | 2 | – | ||
| Post-Mortem determinants | ||||
| Post-mortem delay, median (range) | 08:05 (05:19–10:50) | 05:15 (04:25–05:40) | ||
| Cerebrospinal fluid pH, median (range) | 6.23 (6.22–6.24) | 6.36 (6.35–6.37) | ||
| Brain weight in grams, median (range) | 1027 (1002–1052) | 1197 (1100–1395) | ||
| Braak score, median (range) | 1 (n/a) | 0 (0–0) | ||
ApoE profile information was unknown for these cases. n/a; not available