Table 6.

Selected estimation results: main sample by comparison

	Methoxyflurane	Entonox®	Methoxyflurane	Morphine IV	Methoxyflurane	Paracetamol IV
Estimation Sample
Patients	423	753	423	802	423	278
Observations	2907		3211		1934
Variable
Ineligibilities
Under 18 (Yes = 1)	-0.064	-	-0.053	-	-0.075	-
Pain mild/none (Yes = 1)	-1.862**	-	-1.776**	-	-1.929**	-
GCS ineligible/missing (Yes = 1)	-0.779**	-	-0.740**	-	-0.796**	-
Trauma ineligible (Yes = 1)	0.284	-	0.271	-	0.312	-
Demographics
Sex (F = 0, M = 1)	-0.402**	-0.285**	-0.387**	-0.048	-0.409**	-0.232
Age (years)	-0.003	-0.002	-0.003	-0.001	-0.003	-0.002
Trauma #1 (Yes = 1)	(reference)	(reference)	(reference)	(reference)	(reference)	(reference)
Trauma #2 (Yes = 1)	-0.152	0.222	-0.143	-0.157	-0.154	-0.228
Trauma #3 (Yes = 1)	-0.362*	0.019	-0.344*	-0.229	-0.359*	-0.136
Trauma #4 (Yes = 1)	-0.537**	-0.038	-0.502**	-0.187	-0.528**	-0.090
Trauma #5 (Yes = 1)	-0.048	0.062	-0.042	0.248	-0.041	-0.211
Trauma #6 (Yes = 1)	-0.650	-0.048	-0.622	-0.047	-0.658	0.181
Pathways
Time, $t$	-0.071**		-0.108**		-0.081**
Time squared, $t^2$	0.001**		0.001**		0.001**
Methoxyflurane, $d$	0.730**	-	0.422	-	0.914**	-
Methoxyflurane x Time, $\mathit{dt}$	-0.135**	-	-0.088**	-	-0.128**	-
Methoxyflurane x Time2, $d{t}^2$	0.003**	-	0.002**	-	0.003**	-
Medicine Use
Nonadherence (Yes = 1)	0.707*	-	0.674*	-	0.724*	-
Side-effect (Yes = 1)	0.064	-	0.069	-	0.085	-
Discontinue early (Yes = 1)	0.399	-	0.372	-	0.402	-
Influence Entonox® (Yes = 1)	-0.046	-	-0.019	-	-0.051	-
Influence potency 1 (Yes = 1)	0.003	-	-0.003	-	0.001	-
Influence potency 2 (Yes = 1)	-0.003	-	-0.006	-	-0.004	-
Influence potency 3 (Yes = 1)	0.253	-	0.237	-	0.270	-

^*p < 0.05

^**p < 0.01

The trauma numbering plan is given in Table 4