. 2022 Jul 7;22:122. doi: 10.1186/s12873-022-00664-y

Table 7.

Scenario results: per protocol by comparator

Comparison	Predicted Pain Pathway	Duration in severe pain		Time to least pain		Level of least pain
		Time (mins)	p-value	Time (mins)	p-value	Pain	p-value
Methoxyflurane	$0.763 + I \{t \geq 0.5\} [0.868 - 0.211 t + 0.004 t^{2}]$	10.54 (se = 0.70)	-	26.94 (se = 0.74)	< 0.001	-1.97 (se = 0.18)	< 0.001
vs Entonox®	$0.763 + I \{t \geq 0.5\} [0.799 - 0.072 t + 0.001 t^{2}]$	^a	-	44.96 (se = 2.49)	< 0.001	-0.82 (se = 0.18)	< 0.001
Methoxyflurane	$0.441 + I \{t \geq 0.5\} [0.540 - 0.200 t + 0.004 t^{2}]$	10.47 (se = 0.69)	< 0.001	27.00 (se = 0.75)	< 0.001	-2.16 (se = 0.20)	0.010
vs Morphine IV	$0.441 + I \{t \geq 1\} [0.550 - 0.111 t + 0.001 t^{2}]$	20.09 (se = 1.12)	< 0.001	42.77 (se = 1.48)	< 0.001	-1.81 (se = 0.19)	0.010
Methoxyflurane	$0.896 + I \{t \geq 0.5\} [1.002 - 0.214 t + 0.004 t^{2}]$	9.66 (se = 0.68)	< 0.001	27.07 (se = 0.76)	< 0.001	-1.89 (se = 0.28)	< 0.001
vs Paracetamol IV	$0.896 + I \{t \geq 5\} [1.328 - 0.091 t + 0.001 t^{2}]$	37.53 (se = 6.58)	< 0.001	45.77 (se = 3.11)	< 0.001	-0.76 (se = 0.29)	< 0.001

^aNot predicted to exit severe pain