Table 2.
Unadjusted and adjusted odds ratios (OR) or β coefficients for pregnancy outcomes in women with vs. without history of infertilitya
| Unadjusted | Model 1 | Model 2 | ||||
|---|---|---|---|---|---|---|
| OR | 95% CI | OR | 95% CI | OR | 95% CI | |
| Gestational glucose tolerance status (n = 1984) | ||||||
| Isolated hyperglycemia vs. Normoglycemic | 1.17 | (0.79, 1.72) | 0.99 | (0.67, 1.48) | 0.98 | (0.65, 1.46) |
| Impaired glucose tolerance vs. Normoglycemic | 1.83 | (1.04, 3.21) | 1.70 | (0.94, 3.06) | 1.67 | (0.93, 3.02) |
| Gestational diabetes mellitus vs. Normoglycemic | 1.02 | (0.61, 1.68) | 1.04 | (0.62, 1.75) | 1.02 | (0.60, 1.72) |
| Hypertensive disorders of pregnancy (n = 1988) | ||||||
| Gestational hypertension/preeclampsia vs. Normotensive | 0.87 | (0.59, 1.28) | 0.91 | (0.61, 1.35) | 0.88 | (0.59, 1.31) |
| Gestational weight gain (n = 1971) | ||||||
| Inadequate vs. Adequate | 1.17 | (0.80, 1.71) | 1.19 | (0.80, 1.76) | 1.16 | (0.78, 1.72) |
| Excessive vs. Adequate | 1.18 | (0.91, 1.54) | 1.24 | (0.94, 1.62) | 1.22 | (0.93, 1.61) |
| Birthweight-for-gestational age and sex z-scores (n = 2028)b | ||||||
| Tertile 1 vs. Tertile 2 | 0.89 | (0.68, 1.17) | 1.01 | (0.76, 1.34) | 1.01 | (0.76, 1.35) |
| Tertile 3 vs. Tertile 2 | 0.97 | (0.74, 1.28) | 0.94 | (0.71, 1.25) | 0.92 | (0.69, 1.22) |
| Preterm birth (n = 2029) | ||||||
| Yes vs. No | 1.24 | (0.82, 1.87) | 1.41 | (0.92, 2.16) | 1.40 | (0.91, 2.13) |
| Birth outcome (n = 2201) | ||||||
| Pregnancy loss vs. Live birth c | 1.20 | (0.82, 1.76) | 1.06 | (0.72, 1.58) | 1.09 | (0.73, 1.62) |
| β | 95% CI | β | 95% CI | β | 95% CI | |
| Average SBP across pregnancy, mmHgd | 0.89 | (0.13, 1.64) | 0.93 | (0.17, 1.69) | 0.72 | (0.02, 1.42) |
| Average DBP across pregnancy, mmHgd | 0.59 | (0.05, 1.13) | 0.57 | (0.01, 1.13) | 0.40 | (−0.12, 0.93) |
Model 1: age at enrollment (18–29, 30–34, ≥35 years), race/ethnicity (white, Black, Asian, Hispanic, other), age at menarche (<12, 12–14, 15 years)
Model 2: model 1 + pre-pregnancy BMI (continuous) and pregnancy smoking status (former, smoker during pregnancy, never smoker)
DBP diastolic blood pressure, SBP systolic blood pressure
aThe sample may not add 2201 in some outcomes due to missing outcome data. Women without history of infertility are the reference group
bMean (SD) birthweight-for-gestational age and sex z-scores in tertile 1: −0.86 (0.48); tertile 2, 0.17 (0.24); tertile 3, 1.25 (0.50)
cPregnancy loss includes stillbirth (n = 9) and miscarriage (n = 163)
dβ coefficient obtained from mixed regression models; based on n = 2023