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. 2022 Jul 7;17:344. doi: 10.1186/s13018-022-03207-0

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Circ-FOXM1 could regulate the expression level of FOXM1 post-transcriptionally. a From GEPIA database, we found the upregulation of FOXM1 in sarcoma (SARC) tissues. b qRT-PCR examined the relatively high expression of FOXM1 in OS cells, in comparison with normal hFOB1.19 cells. c The mRNA expression and protein level of FOXM1 were detected in cells transfected with sh-NC or sh-circ-FOXM1#1/2 through qRT-PCR and western blot analyses. d Luciferase reporter assay detected the impact of circ-FOXM1 knockdown on FOXM1 transcription. e RIP assay confirmed the coexistence of circ-FOXM1 and FOXM1 in Ago2-assembled RISCs. *P < 0.05, **P < 0.01