Table 5.

New histopathological nomenclature (HISTALDO) of aldosterone-producing adrenal lesions in patients with unilateral primary aldosteronism.

Aldosterone-producing Lesions (HISTALDO)	Size	HE visible	Histology
Aldosterone-producing adenoma (APA)	> 10mm	Yes	classical
Aldosterone-producing nodule (APN)	< 10mm	Yes	classical*
Aldosterone-producing micronodule (APM)	Microscopic	No	non-classical
Aldosterone-producing diffuse hyperplasia	Continuous layer of ZG cells	Yes	non-classical

*Non-classical in multinodular forms; HE, hematoxylin-eosin; ZG, zona glomerulosa.