Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
The crosstalk between p53, Mdm2 and EMT transcription factors. The wild-type p53 forms the complex with Mdm2 and EMT-TFs mediating their polyubiquitination and proteasomal degradation. TP53 mutations abolish the ability of p53 to associate with EMT-TFs and to form the complex with Mdm2 that results in EMT-TFs stabilization and promotion of EMT process.
