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. 2022 Jan 13;2:828697. doi: 10.3389/fragi.2021.828697

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Copyright © 2022 Frasca, Romero, Garcia, Diaz and Blomberg.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of aging and obesity on the secretion of autoimmune IgG antibodies. Plasma samples were isolated from Y_L, E_L, Y_O and E_O individuals and analyzed by ELISA for the presence of AD-specific (A) or MDA-specific (D) IgG. B cells, isolated from the same individuals in A using magnetic beads, were stimulated for 8 days with CpG, supernatants were collected after 8 days and AD-specific (B) or MDA-specific (E) IgG were measured by ELISA. Correlations of AD-specific (C) and MDA-specific (F) IgG in plasma and culture supernatants. Mean comparisons between groups were performed by two-way ANOVA: *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. Correlations were calculated by bivariate Pearson’s correlation analyses.