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. 2022 Jan 20;2:790702. doi: 10.3389/fragi.2021.790702

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Copyright © 2022 Demirel-Yalciner, Sozen and Ozer.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Unfolded protein response signaling with their regulating microRNAs. miRNAs have a crucial role in shaping the UPR, while miRNA expression is also regulated by UPR. miR-181, miR-30, miR-199a, miR-495, and miR-375 negatively regulates GRP78. On the other hand, miR-322 suppresses IRE1. XBP1 and RIDD signaling, members of IRE1 branch in UPR, regulate miR-153, miR-346, miR-34a, miR-17, miR-96, and miR-125b. Additionally, miR-34c, miR-665, and miR-30c are known to target XBP1, while miR-26a suppresses eIF2α, reducing the protein translation. Certain miRNAs also form a link between UPR branches. In this direction, PERK-mediated miR-30c activation inhibits XBP1 pathway and establishes a negative crosstalk between PERK and IRE1 branches of UPR.