TABLE 1.

MicroRNA-mediated ER stress regulation during age-related diseases.

miRNA	ER stress	Age-related diseases
miR-181a	Suppresses GRP78 expression	Obesity (Mesitov et al., 2017)
miR-199a
miR-30c	Reduces ER stress	Obesity (Menikdiwela et al., 2019)
miR-708	Induces ER stress	Obesity (Menikdiwela et al., 2019)
miR-143
miR-34a	Interacts with ER stress	NAFLD (Gjorgjieva et al., 2019)
miR-122	Decreases UPR-mediated apoptosis	NAFLD (Gjorgjieva et al., 2019)
miR-30	Downregulates of XBP-1 expression	NAFLD (Gjorgjieva et al., 2019)
miR-26a	Targets the eukaryotic initiation factor 2α and decrease ER stress and hepatic steatosis	Hepatic steatosis (Xu et al., 2021)
miR-99b	Induces ER stress	Alzheimer's disease (Ye at al., 2015)
miR-100
miR-16-1	Inhibits Hsp70 and promotes α-synuclein aggregation	Parkinson's disease (Zhang and Cheng, 2014)
miR-7	Reduces ER stress	Parkinson's disease (Shen et al., 2021)
miR-29a	Induces ER stress	Amyloid lateral sclerosis (Nolan et al., 2014)
miR-103	Induces ER stress	Atherosclerosis (Jiang et al., 2020)
miR-451-a	Induces ER stress	Colorectal cancer (Xu et al., 2019)
miR-663	Induces ER stress	Hepatocellular carcinoma (Huang et al., 2016)