TABLE 2.

ER stress-mediated miRNA regulation during age-related diseases.

ER stress	miRNA	Functions
IRE1α inhibition	Induces miR-34a	Protective effects against Aβ-induced injury in SH-SY5Y cells (Li et al., 2019)
PERK	Suppresses miR-24	Protection against mitochondrial dysfunction in heart failure (Shimizu et al., 2020)
UPR activation	Inhibits mir 199a and mir214	Regulates tumor survival and progression (Duan et al., 2012)
RIDD activation	Degrades pre-miR-200 and pre-miR-34	Prevents hepatic steatosis (Wang et al., 2018)