Table 1.

Animal model's strengths and limitations in aging research.

Models of Aging	Strengths	Limitations
Caenorhabditis elegans	Short lifespan. Fast evaluation of interventions. Low costs.	Invertebrate model. Low translationality to humans.
Drosophila melanogaster	Short lifespan. Fast evaluation of interventions. Low costs.	Invertebrate model. Low translationality to humans.
Saccharomyces cerevisiae	Short lifespan. Fast evaluation of interventions. Low costs.	Invertebrate model. Low translationality to humans.
Nothobranchius furzeri	Appropriate for evaluation of interventions	Organs are quite different from those in humans.
Senescence prone inbred strains	Appropriate for evaluation of interventions	Significant differences at a pharmacokinetic level. Lifespan extension could vary between rodent's genders.
Genetically heterogeneous (HET) mouse model	Developed by the National Institute on Aging interventions testing program as the most adequate mammal mice model in aging	Significant differences at a pharmacokinetic level. Lifespan extension could vary between rodent's genders.
Rodent models of progeria	Reduction in time, labor and costs for lifespan studies, as well as the ability to target accelerated aging to specific organs.	Effects of premature aging, not aging itself. Significant differences at a pharmacokinetic level.
Non-human primate models of aging	Best extrapolation of the results to our species.	Expensive. Long time to obtain results.