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. 2021 Aug 10;2:719342. doi: 10.3389/fragi.2021.719342

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Copyright © 2021 Jo, Zhang, Ueno, Yamamoto, Weiskopf, Nagao, Yamanaka and Hamazaki.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Immunophenotyping of SARS-CoV-2-reactive CD8⁺ T cells from young CMV⁺ or CMV⁻ individuals. (A,B) Percentages of NP, CM, EM and TEMRA cells in total CD8⁺ (A) or in SARS-CoV-2-reactive AIM⁺CD8⁺ T cells (B) from CMV seronegative (CMV(−)) and CMV seropositive (CMV(+)) individuals. (C) Frequency of CD28⁻ and CD57⁺ cells among SARS-CoV-2-specific AIM⁺CD8⁺ T cells from CMV⁺ (n = 14) and CMV⁻ (n = 16) individuals. Each dot represents one donor. Data are shown as the median ± IQR. Statistical comparisons across cohorts were performed using the Mann-Whitney test.