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. 2022 Feb 2;2:803482. doi: 10.3389/fragi.2021.803482

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Copyright © 2022 Chen, De Angulo, Guo, More, Ochsner, Lopez, Saul, Pang, Sun, McKenna and Tong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mammalian Phenotype Ontology Analysis Of Nodes With Significant HCT Intersections With aPU.1KO-Induced and Repressed Gene Sets. (A) Enrichment of nodes encoded by genes that map to the MPO term “abnormal energy expenditure” (AEE) among nodes that have significant HCT intersections with aPU.1KO-induced genes. (B) Enrichment of nodes encoded by genes that map to the MPO terms “decreased brown adipose tissue amount”, “decreased core body temperature” or “impaired adaptive thermogenesis” (collectively referred to as THERMO genes) among nodes that have significant HCT intersections with aPU.1KO-induced genes. (C) Enrichment of nodes encoded by genes that map to the MPO term “abnormal cytokine levels” (ACL) among nodes that have significant HCT intersections with aPU.1KO-repressed genes. (D) Enrichment of nodes encoded by genes that map to the MPO term “impaired glucose tolerance” (IGT) among nodes that have significant HCT intersections with aPU.1KO-induced genes. Please refer to the Methods for details of the analysis.