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. 2022 Jan 26;2:821904. doi: 10.3389/fragi.2021.821904

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Copyright © 2022 Guzman, Judge, Shigdar, Paul, Davis, Macpherson, Markworth, Van Remmen, Richardson, McArdle and Brooks.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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GCV⁺ muscle showed reduced expression of p16 ^INK4A. (A) p16-3MR mice were given ganciclovir (GCV⁺) or vehicle (GCV⁻) via intraperitoneal (IP) injection at 20-month of age for 10 days over 2 weeks. Additional 5-day treatments were administered over 1 week in five subsequent months until sacrifice after 6 months. Tissue was harvested at 26-month of age. (B) p16 mRNA relative to 18s mRNA was reduced nearly ∼50% in gastrocnemius muscles of GCV⁺ mice compared to saline treated controls (GCV⁻). Bars show the mean ± SEM of three to five mice per group with dots representing data from each individual mouse. Blue and red data points represent male and female mice, respectively. ** Denotes p < .001 between groups for each tissue by one-way ANOVA with Tukey post-hoc test.