FIGURE 5.

Plasma inflammatory factors and skeletal muscle cytokine mRNA expression were largely unaffected with p16-positive cell deletion. (A) Plasma protein levels (pg/ml) for 22 inflammatory mediators are shown for saline treated controls (GCV⁻), combined male and female GCV treated mice, GCV⁺ (all), male GCV treated mice, GCV⁺ (Male), and female GCV treated mice, GCV⁺(Female). (B) TNFα and IL-6 mRNA expression relative to 18s mRNA in gastrocnemius (GTN) muscles were not significantly different in young, GCV⁻, and GCV⁺ mice. Bars show the mean ± SEM of three to eight mice per group with dots representing data from each individual mouse. *Denotes p < .05 between groups by one-way ANOVA.