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. 2021 Apr 29;2:665637. doi: 10.3389/fragi.2021.665637

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Copyright © 2021 Lanfermeijer, de Greef, Hendriks, Vos, van Beek, Borghans and van Baarle.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The phenotype of CMV-specific and EBV-specific T cells is affected differently by age. (A–D) Phenotype analysis of both CMV^A2−NLV-specific (red) and EBV^A2−GLC-specific CD8⁺ T cells (blue) plotted against age. (A) Percentage of Temra cells (CD27–, CD45RO–). (B) Geometric Mean of the fluorescent intensity of CCR7. Percentage of KLRG-1⁺ (C) and CD57⁺ (D) within Dextramer⁺ CD8⁺ T cells. Solid lines indicate a slope significantly (p < 0.05) different from a slope of 0, whereas a dotted line indicates no significant difference. Only donors with a sufficient T-cell response (at least 25 cells) were used for the phenotypical staining. Correlations were tested with Spearman's rank correlation coefficient.