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. 2022 Mar 24;3:853588. doi: 10.3389/fragi.2022.853588

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Copyright © 2022 Vakkayil and Hoppe.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Temperature-dependent regulation of longevity. Increased lifespan at low temperatures is regulated by signals involving germline stem cells (1), AFD and IL1 neurons (1 and 2), TRPA-1 (3), the co-chaperone DAF-41 (4), and fatty acids (5). AFD, AWC, and ASI neurons, and HSF-1 maintain lifespan at higher temperatures (6), overexpression of rpn-6.1 prolongs it (7), and ASJ neurons and DAF-41 shorten lifespan at higher temperatures (8).