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. 2021 Jul 9;2:714239. doi: 10.3389/fragi.2021.714239

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Copyright © 2021 Abbas and Akbar.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The benefits and detriments of NKR expression on healthy CD8⁺ T cells. Healthy CD8⁺ T cells expressing NKRs harness cytotoxic targeting of many cell types. NKR expression allows for the elimination of senescent fibroblasts as well as cancer cells which present the MICA/B ligands. However, NKR expression on CD8⁺. T cells can drive healthy tissue destruction via targeting of endothelial cells, muscle cells, and epithelial cells which also present MICA/B which is facilitated by various cytokines: IL-15, TNFα and IL-1β.