Table 1.

Summary of the key genetic, behavioral and neuroimaging studies on msP rats.

Type of study	Result	Reference
Genetic	msP rats show innate upregulation of CRF1-R expression and density in multiple corticolimbic regions.	Hansson et al. (2006)
Genetic	Voluntary alcohol consumption produces down-regulation of Crhr1 transcript levels in multiple corticolimbic regions.	Hansson et al., 2007
Genetic	Genetic polymorphism in the CRF1-R promoter region is associated to an increased sensitivity to the effects of the pharmacological blockade of CRFI-R.	Ayanwuyi et al., 2013
Genetic	1 Polymorphism in the CRF1-R gene plays a role in shaping the high anxious phenotype of msP rats.	Cippitelli et al. (2015)
Genetic	msP rats show innate upregulation of N/OFQ and NOP mRNA expression in multiple corticolimbic regions.	Economidou et al., 2008
Behavior	Access to alcohol reduce the anxious and depressive phenotype of msP rats.	Ciccocioppo et al., 1999
Behavior	Alcohol induces conditioned place preference in msP rats.	Ciccocioppo et al., 1999
Behavior	msP rats are highly motivated to lever press for alcohol and show high level of seeking behavior in response to stress and environmental cues.	Ciccocioppo et al., 2004; Cippitelli et al., 2008
Behavior	msP rats exhibit a robust ADE when they are returned to alcohol after a forced abstinent period.	Perfumi et al., 2005
Behavior	Characterization of alcohol-addiction phenotype in msP rats based on the 0/3 crit model.	Domi et al. (2019)
Neuroimaging	Innate reduction of gray matter volume in different thalamic and cortical regions in msP rats.	Gozzi et al. (2013)
Neuroimaging	Microstructural changes in white matter after voluntary alcohol drinking associated to a decreased extracellular space tortuosity.	De Santis et al., 2019; De Santis et al., 2020
Neuroimaging	Amphetamine challenge induces strong functional responses in the extended amygdala of msP rats.	Bifone et al. (2019)