Figure 1:

A) Intestinal Enteroendocrine cells (EECs) sense luminal cues from nutrients and in response secrete hormones into the basal side that can communicate with neighboring cells, other segments of the small intestine and even distant organs. B) The differentiation of EECs in the small intestinal is influenced by signaling pathway gradients along the crypt-villus axis. They mature along the crypt to villus axis while changing gene expression leading to secretion of specific peptides in response to luminal cues. C) A time course of selected early vs intermediate vs late genes or TFs were listed.