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The pathogenic mechanisms of skin hyperpigmentation. Melanin synthesis begins with catalysation of the substrates phenylalanine and tyrosine to produce L-DOPA via tyrosinase. The pathways are then divided into eumelanogenesis or pheomelanogenesis. The other melanogenic enzyme is TRP-1 for eumelanogenesis. Resveratrol is a direct tyrosinase inhibitor. It also can inhibit melanogenic enzymes.
