Table 3.
Anti-inflammatory activity of resveratrol and its derivatives.
| Compound | Experimental model | Cell or animal type | Outcomes offered by the compound | Reference |
|---|---|---|---|---|
| Resveratrol | In vitro hyperproliferation | Human keratinocytes | Resveratrol restrained keratinocyte proliferation via aquaporin 3 inhibition | [115] |
| Resveratrol | In vivo psoriasiform plaque | Balb/c mouse | Oral resveratrol alleviated the severity of scaling and skin redness | [116] |
| Resveratrol | In vivo psoriasiform plaque | Balb/c mouse | Topical resveratrol reduced skin thickness and edema | [118] |
| Resveratrol-enriched rice | In vivo AD-like lesion | NC/Nga mouse | The rice reduced scratching frequency and dermatitis severity | [120] |
| Resveratrol | In vivo AD-like lesion | Balb/c mouse | Oral resveratrol reduced skin thickness and immune response | [121] |
| Resveratrol | In vivo AD-like lesion | Balb/c mouse | Oral resveratrol downregulated Th2-type cytokines | [122] |
| Pterostilbene | In vivo contact dermatitis-like skin | C57BL/6 mouse | Oral pterostilbene attenuated erythema and immune cell infiltration | [123] |
| Polydatin | In vitro inflammation | Human keratinocytes | Polydatin inhibited ERK phosphorylation and NF-κB activation | [124] |
| Polydatin | In vitro inflammation | HaCaT cells | Polydatin inhibited MCP-1, TNF-α, and IL-6 | [125] |
| Polydatin | In vitro inflammation | HaCaT cells | Polydatin inhibited TNF-α, IL-6, and IL-8 | [126] |
| Resveratrol and quercetin in liposomes | In vitro uptake and in vivo inflammation | Dermal fibroblasts and CD-1 mouse | The liposomes increased cellular uptake and reduced edema and neutrophil infiltration | [127] |
| Resveratrol in niosomes | In vitro skin absorption and in vivo inflammation | Wistar rat | The enhanced resveratrol skin absorption with reduced edema | [129] |
| Resveratrol and DHA in SLNs | In vitro inflammation | HaCaT cells | DHA could synergize with resveratrol in SLNs to inhibit cytokine expression | [131] |
| Resveratrol in SLNs | In vivo contact dermatitis-like skin | Mouse | SLNs inhibited skin edema | [132] |
AD, atopic dermatitis; DHA, docosahexaenoic acid; ERK, extracellular signal-regulated kinase; IL, interleukin; MCP-1, monocyte chemotactic protein-1; NF-κB, nuclear factor-κB; SLNs, solid lipid nanoparticles; TNF-α, tumor necrosis factor-α.