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. 2022 Jul 7;13:3921. doi: 10.1038/s41467-022-30763-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 9 — Box and whisker plots represent median and range of low-to-high value points in each group. The samples are divided into three groups- negative, vaccinated, and convalescent depending on their vaccination status or previous exposure to SARS-CoV-2 [negative (n = 7) versus weak (n = 8), moderate (n = 13), and strong positive (n = 18)]. Negative group corresponds to individuals with naïve serum in terms of vaccination or SARS-CoV-2 exposure. Vaccinated samples belong to individuals who received two doses of Pfizer/BioNTech vaccine irrespective of previous exposure to SARS-CoV-2 (convalescent and corresponding convalescent+vaccinated individuals are represented as ▴). Convalescent group is further subdivided into low, moderate and high based on their Spike-specific IgG titres. ID50 values for USA-WA1/2020 are compared to those for B.1.1.7 (A), B.1.351 (B), rTriple (C) and rE484K (D). Two-sided Mann–Whitney U tests were performed to calculate statistical differences. The box-whisker plots show all minimum to maximum data points, with respective medians and interquartile range. The fold change was calculated individually for each sample and represented as average fold change for each group. Dotted line (LOD). Source data are provided as a Source Data file.