Table 3.

The association of urinary caffeine metabolites and the risk of the all-cause death in CVD population.

Variables	Model 1	P	Model 2	P	Model 3	P
	HR (95%CI)		HR (95%CI)		HR (95%CI)
1-methyluric acid, umol/L	1.002 (1.000–1.003)	0.006	1.002 (1.000–1.003)	0.004	1.001 (1.000–1.003)	0.142
3-methyluric acid, umol/L	1.052 (1.019–1.084)	0.002	1.055 (1.017–1.093)	0.006	1.037 (0.982–1.091)	0.198
7-methyluric acid, umol/L	1.002 (0.999–1.004)	0.139	1.002 (1.000–1.005)	0.097	1.002 (0.996–1.007)	0.551
1,3-dimethyluric acid, umol/L	1.004 (0.999–1.009)	0.095	1.004 (0.999–1.008)	0.133	1.003 (0.996–1.011)	0.383
1,7-dimethyluric acid, umol/L	1.003 (1.000–1.005)	0.032	1.002 (1.000–1.004)	0.055	1.002 (0.998–1.005)	0.310
3,7-dimethyluric acid, umol/L	1.016 (0.952–1.080)	0.624	1.029 (0.971–1.087)	0.334	1.033 (0.959–1.107)	0.391
1,3,7-trimethyluric acid, umol/L	1.015 (0.985–1.045)	0.334	1.014 (0.987–1.042)	0.314	1.017 (0.978–1.057)	0.398
1-methylxanthine, umol/L	1.002 (0.999–1.005)	0.188	1.003 (1.000–1.006)	0.020	1.005 (1.000–1.009)	0.035
3-methylxanthine, umol/L	1.002 (1.000–1.004)	0.059	1.002 (1.000–1.004)	0.079	1.001 (0.997–1.005)	0.662
7-methylxanthine, umol/L	1.001 (0.999–1.002)	0.323	1.001 (1.000–1.003)	0.150	1.001 (0.999–1.004)	0.274
1,3-dimethylxanthine (theophylline), umol/L	0.978 (0.900–1.057)	0.586	0.994 (0.927–1.061)	0.865	1.007 (0.926–1.087)	0.869
1,7-dimethylxanthine (paraxanthine), umol/L	0.997 (0.987–1.007)	0.589	1.003 (0.993–1.014)	0.529	1.007 (0.990–1.025)	0.414
3,7-dimethylxanthine (theobromine), umol/L	0.999 (0.992–1.006)	0.698	0.999 (0.992–1.005)	0.719	0.995 (0.980–1.010)	0.524
1,3,7-trimethylxanthine (caffeine), umol/L	1.010 (0.993–1.027)	0.261	1.010 (0.994–1.027)	0.233	1.014 (0.990–1.039)	0.243
AAMU, umol/L	1.001 (1.000–1.002)	0.020	1.002 (1.000–1.003)	0.005	1.001 (1.000–1.003)	0.095

HR, hazard ratios; CI, confidence interval.

Model 1: unadjusted.

Model 2: adjusted for age and BMI.

Model 3: adjusted for age, BMI, cancer, eGFR, energy, the history of CVD medications, carbohydrate and family PIR.