Table 1.
Demographics AD-CBS and Controls
| p-values | ||||||
|---|---|---|---|---|---|---|
|
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| AD-AS n=42 | AD-CBS n=43 | CBD-CBS n=15 | AD-AS vs AD-CBS | AD-AS vs CBD-CBS | AD-CBS vs CBD-CBS | |
|
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| Clinical features | ||||||
|
| ||||||
| Sex, male (%) | 18 (43%) | 17 (40%) | 10 (63%) | |||
| Age at onset, years | 63 (57,73) | 61 (55,69) | 64 (55,69) | |||
| Age at death, years | 73 (67, 78) | 70 (64,77) | 71 (62, 77) | |||
| Disease duration | 9 (7, 11) | 9 (7, 1) | 7 (5, 8) | 0.05 | 0.02 | |
|
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| Neuropathologic features | ||||||
|
| ||||||
| Brain weight | 960 (920, 1070) | 980 (860, 1060) | 1160 (1040, 1295) | <0.001 | <0.001 | |
| Braak stage | VI | VI | II-III (I, III) | <0.001 | <0.001 | |
| Thal phase | 5 | 5 | 1 (0, 3) | <0.001 | <0.001 | |
| TDP-43 | 12/42 (28%) | 7/43 (16%) | 2/15 (13%) | 0.008 | ||
| Amygdala Lewy bodies | 6 | 5 | none | |||
|
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| Regions of cortical atrophy at autopsy | ||||||
|
| ||||||
| Superior frontal gyrus | 0 (0%) | 4 (10%) | 6 (40%) | 0.05 | <0.001 | 0.01 |
| Paracentral lobule | 2 (5%) | 9 (22%) | 2 (13%) | 0.03 | ||
| Temporal, anterior | 8 (21%) | 1 (2%) | 0 (0%) | 0.01 | ||
| Parietal | 9 (23%) | 10 (24%) | 1 (7%) | |||
| Occipital | 13 (33%) | 19 (43%) | 3 (20%) | 0.05 | ||
All variables are analyzed with Kruskal-Wallis ANOVA on Ranks and displayed as median (25th and 75th range), unless otherwise noted. Post hoc pairwise comparisons were performed with Mann-Whitney rank sum test. Only statistically significant p-values are shown.