Table 3.

Neuropathological characteristics of AD-CBS and controls

				p-values
	AD-AS n=42	AD-CBS n=43	CBD-CBS n=15	AD-AS vs AD-CBS	AD-AS vs CBD-CBS	AD-CBS vs CBD-CBS
Thickness of corpus callosum
	3.6 (3.1, 4.4)	3.3 (2.7, 4.4)	3.4 (2.6, 4.1)
NFT counts in neocortex with thioflavin S fluorescent microscopy
MF	11 (6, 15)	8 (5, 16)	0 (0, 0)		<0.001	<0.001
ST	15 (12, 22)	10 (6, 15)	0 (0, 0)	0.002	<0.001	<0.001
IP	15 (11, 21)	12 (8, 20)	0 (0, 0)		<0.001	<0.001
MTR	2 (1, 3)	4 (2, 6)	0 (0, 0)	<0.001	<0.001	<0.001
VC	3 (2, 6)	3 (1, 7)	0 (0, 0)		<0.001	<0.001
SP counts in neocortex with thioflavin S fluorescent microscopy
MTR	26 (16, 38)	34 (20, 43)	0 (0, 0)		<0.001	<0.001
VC	50 (30, 50)	40 (30, 46)	0 (0, 8)		<0.001	<0.001
Neuronal loss scores on hematoxylin eosin stained sections
nbM	3 (2, 3)	3 (2, 3)	0 (0, 0)		<0.001	<0.001
SN	0.5 (0, 1)	1 (0.5, 1.5)	3 (2.9, 3.0)	<0.001	<0.001	<0.001
Phospho-tau burden with CP-13 immunohistochemistry
CING	12 (5.3, 18)	7.7 (4.5, 17)	3.7(2.7, 4.6)		<0.001	0.005
SFG	15 (8.1, 22)	11 (6.8, 24)	4.2 (2.7,7.5)		<0.001	<0.001
CC	0.17 (0.1, 0.3)	0.11 (0.1, 0.2)	0.82(0.6,1.8)	0.01	<0.001	<0.001
MTR	3.8 (1.5, 8.6)	10 (6.5, 14)	9.1 (7.7, 14.8)	<0.001	<0.001
SS	7.1 (4.0, 12)	12.8 (6.7, 22)	1.6 (0.9, 4.2)	0.007	<0.001	<0.001
WM (MCtx)	0.2 (0.1,0.3)	0.2 (0.1, 0.3)	4.1 (2.3, 6.1)		<0.001	<0.001
Microglial burden with CD68 immunohistochemistry
CING	0.16 (0.08, 0.26)	0.09 (0.05, 0.22)	0.14 (0.09, 0.28)
SFG	0.19 (0.15, 0.29)	0.16 (0.07, 0.31)	0.19 (0.12, 0.34)
CC	0.62 (0.42, 0.87)	0.52 (0.30, 0.73)	0.97 (0.61, 1.2)		0.01	<0.001
MTR	0.17 (0.11, 0.23)	0.2 (0.11, 0.31)	0.56 (0.32, 0.87)		<0.001	<0.001
SS	0.17 (0.12, 0.23)	0.24(0.12, 0.32)	0.20 (0.12, 0.38)
WM (MCtx)	0.35 (0.26, 0.66)	0.44 (0.24, 0.71)	1.5 (1.2, 2.6)		<0.001	<0.001

All variables are analyzed with Kruskal-Wallis ANOVA on Ranks and displayed as median (25^th and 75^th range), unless otherwise noted. Post hoc pairwise comparisons were performed with Mann-Whitney rank sum test. Only statistically significant p-values are shown. Corpus callosum thickness measures are in centimeters. NFT counts are the maximal number in a representative 400x field. Tau and microglia burden are derived from image analysis of digitized images of stained tissue sections and represent the ratio of positively stained pixels to the total number of pixels in the given region of interest. Abbreviations: NFT = neurofibrillary tangles, SP = senile plaques (both with thioflavin S fluorescent microscopy), MF = middle frontal gyrus, ST = superior temporal gyrus, IP = inferior parietal lobule, MTR = motor cortex, VC = primary visual cortex, nbM = basal nucleus of Meynert, SN = substantia nigra pars compacta, ventrolateral tier, CING = anterior cingulate gyrus, SFG = superior frontal gyrus, CC = corpus callosum at level of anterior cingulate gyrus, MTR = motor cortex, SS = somatosensory cortex, WM (MTR) = white matter beneath motor cortex.