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. 2022 Jul 7;18(7):e1010611. doi: 10.1371/journal.ppat.1010611

Fig 1. SIV-specific CD8+ T cell repertoire fluctuates throughout infection and during ARV treatment.

Fig 1

PBMCs, LN biopsies and BAL were sampled from 7 different SIVmac239X or SIVmac239-infected rhesus macaques during acute infection, chronic infection and after 2–7 months of ARV treatment. (A-G). Clonotypes consisting of more than 1% of the TCR repertoire were represented as percentage of the TCR repertoire during acute and chronic infection and with ARV treatment. “Public” clonotypes are the same clonotype (same V and J segments and same CDR3 amino acid sequence) found in multiple animals in this study, and matching clonotypes previously identified in the VDJdb database. “Shared” clonotypes were those found only in one animal but observed in multiple tissues. “Private” clonotypes were identified in a single anatomical site in a single animal. n = 7 animals. Total cell and TCR sequences numbers are listed above each column.