Table 3.
Distribution of CETP polymorphisms in patients with CAD and healthy controls
| Genotype frequency | Allele frequency | Model | OR (95% CI) | pC | |||
|---|---|---|---|---|---|---|---|
| CETP Taq1B | A5454-G (rs708272) | ||||||
| Control | AA | AG | GG | A/G | |||
| (n = 604) | 187 (0.309) | 285 (0.471) | 132 (0.218) | 0.546/0.454 | Codominant | 1.56 (0.99-2.13) | 0.093 |
| Dominant | 1.48 (1.03-2.14) | 0.032 | |||||
| CAD | 52 (0.241) | 109 (0.504) | 55 (0.261) | 0.493/0.507 | Recessive | 1.23 (0.85-1.78) | 0.281 |
| (n = 216) | Overdominant | 1.18 (0.86-1.62) | 0.310 | ||||
| Log-additive | 1.25 (1.00-1.56) | 0.048 | |||||
| CETP -971 A/G | (rs4783961) | ||||||
| Control | GG | AG | AA | A/G | |||
| (n = 604) | 138 (0.229) | 310 (0.513) | 156 (0.257) | 0.514/0.486 | Codominant | 2.03 (1.20-3.43) | 0.022 |
| Dominant | 1.83 (1.15-2.89) | 0.008 | |||||
| CAD | Recessive | 1.43 (0.92-1.92) | 0.121 | ||||
| (n = 218) | 35 (0.161) | 118 (0.541) | 65 (0.298) | 0.571/0.429 | Overdominant | 1.14 (0.80-1.61) | 0.468 |
| Log-additive | 1.39 (1.08-1.79) | 0.011 |
The p-values were calculated by the logistic regression analysis, and ORs were adjusted for age, gender, blood pressure, BMI, glucose, total cholesterol, HDL-C, LDL-C, triglycerides, and smoking habit. CAD: coronary artery disease; OR: odds ratio; CI: confidence interval; pC: p-value.