Table 2.
Putative factors for immune evasion and sustained survival of M. genitalium.
| Virulence factors | Subcellular location | Function | Reference |
|---|---|---|---|
| P140 | Transmembrane | Adhesion; Motility; Antigenic variation; Internalization | [19,24,28,70] |
| P110 | Transmembrane | Adhesion; Motility; Antigenic variation; Internalization | [19,28,70] |
| MG428 | Unclear | Recombination regulator | [77,78], |
| RecA (mg339) | Cytoplasm | Recombination regulator | [78,79], |
| RuvA (mg358) | Unclear | Recombination regulator | [78,80], |
| RuvB (mg359) | Unclear | Recombination regulator | [78,80] |
| RecU (mg352) | Cytoplasm | Recombination regulator | [81] |
| RrlA (mg220) | Transmembrane | σ accessory protein | [78] |
| RrlB | Unclear | σ accessory protein | [78] |
| MG281 | Transmembrane | Protein M, Antibody-binding | [71,82] |
| Duf31 domain protein | Unclear | Cleavage of Igs (Predicted) | [82] |
| MG186 | Cell membrane; Lipid-anchor | Nuclease, Degradation of NETs (Predicted) | [16,57] |
| MG408 | Cytoplasm | MsrA; Defenses against oxidative stress | [45,83–85] |
| MG448 | Cytoplasm | MsrB | [45,83,85] |
| MG454 | Unclear | Ohr; Detoxification of oxidants | [72] |
| MG149 | Cell membrane; Lipid-anchor | OsmC, Maintaining cellular integrity; Degrading ROS | [56] |
| MG427 | Cytoplasm | OsmC, Detoxification | [72,86] |